Available
Project number:
2025_82
Start date:
October 2025
Project themes:
Main supervisor:
Lecturer in AI in Mental Health
Co-supervisor:
Professor Nikolaos Koutsouleris
Additional Information:
Multimodal Prediction of Psychiatric Outcomes Using Structural Imaging, Blood Biomarkers, and Clinical Data from the KCL CRIS Dataset
Background
Mental health disorders such as schizophrenia, bipolar disorder, and major depression are complex, with highly variable outcomes across patients. This variability makes it challenging to predict how individuals will respond to treatments or how their symptoms will progress. The KCL Clinical Record Interactive Search (CRIS) dataset, containing rich electronic health records, offers a unique opportunity to study mental health outcomes by integrating clinical data with structural brain imaging and blood biomarkers. This multimodal approach provides a deeper understanding of the biological mechanisms underlying psychiatric conditions.
Novelty & Importance
This project is novel in its integration of multimodal data—combining clinical, structural imaging, and blood biomarker information—to predict outcomes across psychiatric diagnoses. While individual data types have been studied in isolation, few have attempted to integrate them in a predictive framework. This comprehensive approach has the potential to improve the accuracy of outcome predictions, ultimately advancing personalized care in psychiatry.
Aims & Objectives
The project aims to develop a predictive model that uses data from the CRIS dataset, structural brain imaging, and blood biomarkers to forecast outcomes for patients with different psychiatric diagnoses. Specific objectives include:
Preprocessing and integrating clinical, imaging, and molecular data.
Developing machine learning models to predict clinical outcomes such as treatment response and symptom progression.
Evaluating model performance across different diagnoses to assess the generalizability of this multimodal approach.
We are now accepting applications for 1 October 2025
How to apply
Candidates should possess or be expected to achieve a 1st or upper 2nd class degree in a relevant subject including the biosciences, computer science, mathematics, statistics, data science, chemistry, physics, and be enthusiastic about combining their expertise with other disciplines in the field of healthcare.
Important information for International Students:
It is the responsibility of the student to apply for their Student Visa. Please note that the EPSRC DRIVE-Health studentship does not cover the visa application fees or the Immigration Health Surcharge (IHS) required for access to the National Health Service. The IHS is mandatory for anyone entering the UK on a Student Visa and is currently £776 per year for each year of study. Further detail can be found under the International Students tab below.
Next Steps
- Applications submitted by the closing date of Thursday 6 February 2025 will be considered by the CDT. We will contact shortlisted applicants with information about this part of the recruitment process.
- Candidates will be invited to attend an interview. Interviews are projected to take place in April 2025.
- Project selection will be through a panel interview chaired by either Professor Richard Dobson and Professor Vasa Curcin (CDT Directors) followed by informal discussion with prospective supervisors.
- If you have any questions related to the specific project you are applying for, please contact the main supervisor of the project directly.
For any other questions about the recruitment process, please email us at