Available
Project number:
2025_66
Start date:
October 2025
Project themes:
Main supervisor:
Reader in Bioinformatics
Co-supervisor:
Professor Gerome Breen, Professor of Psychiatric Genetics, Social, Genetic & Dev Psychiatry
Additional Information:
Investigating the functional role of human endogenous retroviruses using lond-read sequencing
Human endogenous retroviruses (HERVs) are large, polymorphic and highly repetitive sequences that integrated in our genomes up to millions of years ago, as a result of ancient infections. They currently comprise ~8% of our genome, whereas proteins comprise only 1-2%. There is growing evidence implicating HERVs in biological processes including neurodegenerative diseases. However, our understanding of HERVs is limited and their mechanism of action, functional role and variational landscape are poorly understood. In this project we propose to use a new technology, called long-read sequencing, to generate cross-tissue multi-omics data to try to fill such gaps in our understanding of HERVs.
We are now accepting applications for 1 October 2025
How to apply
Candidates should possess or be expected to achieve a 1st or upper 2nd class degree in a relevant subject including the biosciences, computer science, mathematics, statistics, data science, chemistry, physics, and be enthusiastic about combining their expertise with other disciplines in the field of healthcare.
Important information for International Students:
It is the responsibility of the student to apply for their Student Visa. Please note that the EPSRC DRIVE-Health studentship does not cover the visa application fees or the Immigration Health Surcharge (IHS) required for access to the National Health Service. The IHS is mandatory for anyone entering the UK on a Student Visa and is currently £776 per year for each year of study. Further detail can be found under the International Students tab below.
Next Steps
- Applications submitted by the closing date of Thursday 6 February 2025 will be considered by the CDT. We will contact shortlisted applicants with information about this part of the recruitment process.
- Candidates will be invited to attend an interview. Interviews are projected to take place in April 2025.
- Project selection will be through a panel interview chaired by either Professor Richard Dobson and Professor Vasa Curcin (CDT Directors) followed by informal discussion with prospective supervisors.
- If you have any questions related to the specific project you are applying for, please contact the main supervisor of the project directly.
For any other questions about the recruitment process, please email us at