Available
Project number:
2025_64
Start date:
October 2025
Project themes:
Main supervisor:
Co-supervisor:
Additional Information:
ALS in a Global Context: Integrating Genomic and Epigenomic Data from Diverse Populations
Genome-wide association studies (GWAS) have uncovered new ALS genes, but as discoveries become harder, rare variants with smaller effects remain elusive. In addition to genetic factors, epigenetic mechanisms like DNA methylation and histone modifications play a key role in ALS pathogenesis by regulating gene expression. However, most ALS studies focus on populations of European descent (96%), limiting insights into how epigenetic factors influence ALS across diverse populations. To address this gap, the Trans-Ancestral Genetics working group was established to diversify ALS research and better understand gene-environment interactions in different ethnicities. This work is crucial for developing more effective therapeutic approaches and uncovering the full spectrum of ALS biology. By analysing genetic and epigenetic data from a broad range of populations, including those historically underrepresented in ALS research, this project aims to uncover novel genes and molecular pathways associated with ALS. This approach is crucial, as the genetic architecture of ALS can vary significantly across different ethnicities and regions. By bringing these diverse genetic insights to the forefront, the project aims to reveal new aspects of ALS biology, potentially leading to the identification of previously unrecognized therapeutic targets. This, in turn, will guide the development of targeted therapies, addressing the complex and varied nature of ALS. This marks a significant milestone in global ALS research, aiming to enhance the identification of treatment targets for a more inclusive ALS patient population worldwide.
We are now accepting applications for 1 October 2025
How to apply
Candidates should possess or be expected to achieve a 1st or upper 2nd class degree in a relevant subject including the biosciences, computer science, mathematics, statistics, data science, chemistry, physics, and be enthusiastic about combining their expertise with other disciplines in the field of healthcare.
Important information for International Students:
It is the responsibility of the student to apply for their Student Visa. Please note that the EPSRC DRIVE-Health studentship does not cover the visa application fees or the Immigration Health Surcharge (IHS) required for access to the National Health Service. The IHS is mandatory for anyone entering the UK on a Student Visa and is currently £776 per year for each year of study. Further detail can be found under the International Students tab below.
Next Steps
- Applications submitted by the closing date of Thursday 30 January 2025 will be considered by the CDT. We will contact shortlisted applicants with information about this part of the recruitment process.
- Candidates will be invited to attend an interview. Interviews are projected to take place in March 2025.
- Project selection will be through a panel interview chaired by either Professor Richard Dobson and Professor Vasa Curcin (CDT Directors) followed by informal discussion with prospective supervisors.
- If you have any questions related to the specific project you are applying for, please contact the main supervisor of the project directly.
For any other questions about the recruitment process, please email us at
