Available
Project number:
2025_35
Start date:
October 2025
Project themes:
Main supervisor:
Senior Lecturer
Co-supervisor:
Dr Alfredo Iacoangeli
Additional Information:
The role of mitochondria in the causal pathways of neurodegenerative disorders
Background: Human mitochondria play a vital role in regulating key biological processes throughout the body, especially in high-energy tissues like the brain. Mitochondrial dysfunction has been linked to several common neurological disorders, such as Parkinson’s Disease, Alzheimer’s Disease and ALS, but it is unclear whether this dysfunction is a cause or consequence of disease. Using large-scale genetic and gene expression data from human brain regions, we will employ advanced machine learning techniques to model the genetic mechanisms affecting mitochondrial function and integrate protein and metabolite data to assess the downstream effects. These models will then be applied to disease cohorts and electronic health records to explore whether tissue- and cell-type-specific mitochondrial processes contribute to the risk and progression of neurological disorders.
We are now accepting applications for 1 October 2025
How to apply
Candidates should possess or be expected to achieve a 1st or upper 2nd class degree in a relevant subject including the biosciences, computer science, mathematics, statistics, data science, chemistry, physics, and be enthusiastic about combining their expertise with other disciplines in the field of healthcare.
Important information for International Students:
It is the responsibility of the student to apply for their Student Visa. Please note that the EPSRC DRIVE-Health studentship does not cover the visa application fees or the Immigration Health Surcharge (IHS) required for access to the National Health Service. The IHS is mandatory for anyone entering the UK on a Student Visa and is currently £776 per year for each year of study. Further detail can be found under the International Students tab below.
Next Steps
- Applications submitted by the closing date of Thursday 6 February 2025 will be considered by the CDT. We will contact shortlisted applicants with information about this part of the recruitment process.
- Candidates will be invited to attend an interview. Interviews are projected to take place in April 2025.
- Project selection will be through a panel interview chaired by either Professor Richard Dobson and Professor Vasa Curcin (CDT Directors) followed by informal discussion with prospective supervisors.
- If you have any questions related to the specific project you are applying for, please contact the main supervisor of the project directly.
For any other questions about the recruitment process, please email us at