Congratulations to our student, Dina Farran
May 22, 2024
View Dina's Abstract
We are delighted to share that one of our EPSRC DRIVE-Health CDT students and PhD candidate at the IoPPN, Dina Farran, has been awarded 1st prize presentation at the recent Royal College of Psychiatrists Faculty of Liaison Psychiatry annual conference earlier this month. Dina is working under the supervision of Professor Fiona Gaughran and Professor Mark Ashworth and is about to submit her thesis at the end of this month.
In the presentation, Dina summarised her PhD project consisting of a literature review, 2 observational studies, an intervention and 2 qualitative studies. Dina provides further detail below.
Background
Atrial fibrillation (AF), the most prevalent cardiac arrhythmia, is associated with an increased risk of stroke contributing to heart failure and death. In this project, we aim to improve patient safety by screening for stroke risk among people with AF and co-morbid mental illness.
Methods
(a) Conducted a systematic review and meta-analysis on prevalence, management, and outcomes of AF in people with Serious Mental Illness (SMI) versus the general population.
(b) Evaluated oral anticoagulation (OAC) prescription trends in people with AF and co-morbid SMI in King’s College Hospital.
(c) Identified the recorded rates of OAC prescription among people with AF and various mental illnesses and evaluated the association between mental illness severity and OAC prescription in eligible patients in South London and Maudsley (SLaM) NHS Foundation Trust.
(d) Implemented an electronic clinical decision support system (eCDSS) consisting of a visual prompt on patient electronic Personal Health Record to screen for AF-related stroke risk in three Mental Health of Older Adults wards at SLaM.
(e) Assessed the feasibility and acceptability of the eCDSS by qualitatively investigating clinicians’ perspective of the potential usefulness of the eCDSS (pre-intervention) and their experiences and their views regarding its impact on clinicians and patients (post-intervention).
Results
(a) People with SMI had low reported rates of AF. AF patients with SMI were less likely to receive OAC than the general population. When receiving warfarin, people with SMI, particularly bipolar disorder, experienced poor anticoagulation control compared to the general population. Meta-analysis showed that SMI was not significantly associated with an increased risk of stroke or major bleeding when adjusting for underlying risk factors.
(b) Among AF patients having a high stroke risk, those with co-morbid SMI were less likely than non-SMI patients to be prescribed any OAC, particularly warfarin (but not DOACs). However, there was no evidence of a significant difference between the two groups since 2019.
(c) Adjusting for age, sex, stroke and bleeding risk scores, patients with AF and co-morbid SMI were less likely to be prescribed any OAC compared to those with dementia, substance use disorders or common mental disorders. Among AF patients with co-morbid SMI, warfarin was less likely to be prescribed to those having alcohol or substance dependency, serious self-injury, hallucinations or delusions and activities of daily living impairment.
(d) Clinicians were asked to confirm the presence of AF, clinically assess stroke and bleeding risks, record risk scores in clinical notes and refer patients at high risk of stroke to OAC clinics.
(e) Clinicians reported that the eCDSS saved time, prompted them towards guidelines, boosted their confidence, and identified patients at risk. Perceived barriers to using the tool included low admission rate of AF cases, low or insufficient visibility of the alert/awareness of the tool, and impact of the eCDSS on workload.
Conclusions
This study presents a unique opportunity to quantify AF patients with mental illness who are at high risk of severe outcomes, using electronic health records. This has the potential to improve health outcomes and therefore patients' quality of life.
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We’re pleased to announce that Dr Petroula Laiou from King's College London , will deliver our May Seminar Series with her talk, "Bridging the Gap: Turning Academic Research into Clinical Innovation " . Petroula will share her journey of translating cutting-edge academic research into a mission-driven MedTech company. The spinout is pioneering a novel approach to forecasting and preventing seizures in people with drug-resistant epilepsy - an innovation rooted in years of interdisciplinary work at the intersection of clinical neuroscience, signal processing, and artificial intelligence. Dr. Laiou will take the audience through the full translational pathway: from identifying an unmet clinical need, designing and analysing first-in-human studies, and developing a seizure prediction algorithm, to securing translational funding, navigating the intellectual property landscape, and filing an international patent (PCT/GB2024/052456). She will reflect on key lessons learned during her time in the King’s MedTech Accelerator Programme - where the team won the Best Innovation award - and share insights on building bridges between academia and industry, shaping a commercialization strategy, and transitioning from researcher to entrepreneur. The talk will also highlight the challenges and rewards of launching a spinout in the healthcare sector and offer practical advice for PhD students and early-career researchers considering the entrepreneurial route. Seminar Series Event: "Bridging the Gap: Turning Academic Research into Clinical Innovation" Date and Time: Wednesday 7 May 2025, 15:00 – 16.00 hrs (BST) Location: The Lorna Wing Room, SGDP Building, Denmark Hill Campus, London, SE5 8AF Attendance: Mandatory for all DRIVE-Health students, therefore please accept the calendar invitation. Registration: Alumni and wider King's College London research community all welcome - please email drive-health-cdt@kcl.ac.uk to let us know if you would like to attend. Dr. Petroula Laiou is a Research Fellow in Predictive Modelling and Clinical Neuroscience at King’s College London. With a background in mathematics, computational physics, and a PhD in signal analysis, her research bridges computer science, neuroscience, and machine learning. Her work focuses on developing predictive models and digital biomarkers for neurological and psychiatric disorders, including epilepsy and depression. Dr. Laiou led the development of a novel seizure forecasting algorithm using intracranial EEG and cortical responses to electrical stimulation—research that led to the filing of an international patent (PCT/GB2024/052456). She is the recipient of multiple research grants, including an MRC award as Principal Investigator, and her translational work was recognised by the King’s MedTech Accelerator Programme, where her team won the Best Innovation award. She has authored over 40 peer-reviewed publications, presented at major international conferences, and actively contributes to interdisciplinary collaborations across academia, hospitals, and industry.
We were thrilled to welcome Charles Friedman from the University of Michigan Medical School , who delivered our March Seminar Series with his talk, "Why AI and Learning Health Systems Need Each Other " . Charles began by advancing the idea that, while both are extremely important: AI is a means and Learning Health Systems (LHS) are an end--and why it is most important to maintain that distinction. He introduced the socio-technical infrastructure required for high-functioning learning systems and argue that this infrastructure provides a framework, actually a schematic, for successfully implementing AI into healthcare. Charles Friedman is Professor of Learning Health Sciences at the University of Michigan Medical School, where he directs the Knowledge Systems Laboratory. He was formerly Founding Chair of the Department of Learning Health Sciences and the Josiah Macy Jr. Professor of Medical Education. He holds joint appointments in the Schools of information and Public Health. He is editor-in-chief of the open-access journal Learning Health Systems and co-chair of the multi-national movement to Mobilize Computable Biomedical Knowledge. Throughout his career, Friedman has developed and studied methods to improve health, education, and research through innovative applications of information technology. Most recently, Friedman has focused his academic interests and activities on the concept of Learning Health Systems that improve health by marrying discovery to implementation, and the socio-technical infrastructure required to sustain these systems. Friedman is a Distinguished Fellow of the American College of Medical Informatics, and a founding fellow of the International Academy of Health Sciences Informatics. He holds an honorary doctorate from the University of Lucerne in Switzerland for his contributions to the science of Learning Health Systems. Prior to coming to Michigan, Friedman held executive positions at the Office of the National Coordinator for Health IT (ONC) in the U.S. Department of Health and Human Services. Immediately prior to his work in the government, he was Associate Vice Chancellor for Biomedical Informatics, and Founding Director of the Center for Biomedical Informatics at the University of Pittsburgh. Seminar Series Event: "Why AI and Learning Health Systems Need Each Other" Date and Time: Wednesday 26 March 2025, 10:00 – 11.00 hrs (BST) Location: The Anatomy Museum, King's Building, Room K6.36, Strand Campus, Strand, London, WC2R 2LS Attendance: Mandatory for all DRIVE-Health students, therefore please accept the calendar invitation. Registration: Alumni and wider King's College London research community all welcome - please email drive-health-cdt@kcl.ac.uk to let us know if you would like to attend.
